Gingipain proteases from the bacterium Porphyromonas gingivalis confer protection against airway viral infection.

Key Points

• The aim is to evaluate how gingipain proteases influence host responses to viral infections.
• Gingipain proteases were tested for their ability to inhibit host interferon responses.
• The impact of these proteases on viral infectious capacity was assessed.
• Gingipain proteases significantly inhibited host IFN responses.
• Proteases preemptively reduced viral infectious capacity, providing robust protection against respiratory infections.