)-H difunctionalization of 1,2,3,4-tetrahydroisoquinolines and concurrent formation of multiple C-C and C-N bonds. The resulting polycyclic scaffolds are readily transformed into multifunctional photoluminescent materials that display aggregation-induced delayed fluorescence (AIDF) emission. Preliminary biological evaluation revealed that several derivatives potently inhibit key inflammatory mediators in lipopolysaccharide-activated macrophages, indicating their potential as promising anti-inflammatory lead candidates.
Zheng et al. (Mon,) studied this question.