Anti-Inflammatory and Antioxidant Effects of Pilea anisophylla Wedd. (Urticaceae) Extract via the Regulation of the NF-κB Pathway

Key Points

• The study aims to evaluate the anti-inflammatory and antioxidant effects of Pilea anisophylla extract through the modulation of the NF-κB pathway.
• Evaluated the extract's effects on inflammation and oxidative stress in cultured cells.
• Analyzed the modulation of the NF-κB pathway as a mechanism of action.
• Utilized biochemical assays to assess antioxidant activity.
• Pilea anisophylla extract significantly reduced NF-κB activation (p<0.01).
• Showed improved antioxidant capabilities with a 30% increase in cellular antioxidant activity (p<0.05).
• Demonstrated a 25% reduction in inflammatory cytokine levels (p<0.01).