Ambulatory ePWV is an independent risk factor for dementia-related brain pathology in patients with hypertension aged ≥50 years.
Observational (n=893)
Is 24-hour ambulatory estimated pulse wave velocity associated with dementia-related neuroimaging and cognitive function in patients with hypertension?
Ambulatory estimated pulse wave velocity is associated with dementia-related brain pathology in hypertensive patients, suggesting arterial stiffness as a potential target for dementia prevention.
BACKGROUND: Inconsistent links between arterial stiffness and cognition may reflect limited cognitive tests and unaccounted diurnal pulse wave velocity variation. To bridge this knowledge gap, we investigated 24-hour ambulatory estimated pulse wave velocity (ePWV) and its association with dementia-related neuroimaging and cognitive function in hypertension. METHODS: We assessed 893 patients with hypertension aged ≥50 years (mean age, 67.2 years; 52.3% women), including brain magnetic resonance imaging (n=545), global cognitive testing (n=623), and ambulatory ePWV measurements. White matter hyperintensity and hippocampus were quantified via Computational Anatomy Toolbox 12 and Statistical Parametric Maps 12. Cognition was assessed via the Mini-Mental State Examination and Montreal Cognitive Assessment. RESULTS: ≥0.18). Results were consistent for daytime and nighttime ePWV and across key subgroups. CONCLUSIONS: Ambulatory ePWV is an independent risk factor for dementia-related brain pathology. Targeting arterial stiffness represents a promising strategy for dementia prevention.
Cheng et al. (Wed,) conducted a observational in Hypertension (n=893). Ambulatory estimated pulse wave velocity (ePWV) was evaluated on Dementia-related neuroimaging and cognitive function. Ambulatory ePWV is an independent risk factor for dementia-related brain pathology in patients with hypertension aged ≥50 years.