Neuroplastic white matter changes in patients with major depression following lysergic acid diethylamide treatment

Key Points

• This research aims to investigate the effects of LSD treatment on white matter changes in patients with major depression.
• Patients with major depression were administered moderate-to-high doses of LSD.
• Changes in white matter fractional anisotropy (FA) were measured post-treatment, up to 12 weeks.
• Correlation analysis was conducted between FA increases and symptom relief.
• White matter fractional anisotropy (FA) significantly increased post-LSD treatment, particularly in regions associated with depression-related structural abnormalities.
• Post-treatment FA increases correlated with symptom relief within 12 weeks, suggesting potential therapeutic effects.