Chelation of radium with double-armed benzo-rigidified macrocycles for radiopharmaceutical purposes

Key Points

• This research aims to evaluate new chelating agents for radium-223 to enhance its clinical application in targeted alpha therapy.
• Developed double-armed benzo-rigidified macrocycles for chelation.
• Assessed the stability and kinetic inertness of the formed complexes with radium-223.
• The new macrocycles successfully formed stable complexes with radium-223, demonstrating improved chelation characteristics.
• Stability tests showed significantly higher kinetic inertness compared to existing agents.