Anti-RANKL improves muscle dysfunction and strengthens bone in laminin-α2-deficient dy2J/dy2J dystrophic mice.

Key Points

• The research aims to evaluate the effects of anti-RANKL on muscle dysfunction and bone health in laminin-α2-deficient mice.
• Utilized dy2J/dy2J dystrophic mice as a model for the intervention.
• Administered anti-RANKL treatment to assess effects on muscle and bone function.
• Conducted assessments of muscle force and motor performance, though specifics were not detailed.
• Observed improvements in muscle dysfunction and bone strength post anti-RANKL treatment, but not significant enough to enhance absolute muscle force.
• Global motor performance remained unaffected, indicating limitations of the treatment.