What does this research mean for the field?

Despite the proven pathophysiological efficacy of treat-to-target urate-lowering therapy in resolving gout tophi, its practical implementation in primary care settings remains a significant challenge. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to explore the implementation of treat-to-target approaches for gout management in primary care settings.

May 17, 2026The Journal of Rheumatology0 citations

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If Treat-to-Target Works for Gout, Who Will Implement It in Primary Care?

JTJuan Sebastián Therán-LeónUniversidad Autónoma de Bucaramanga AOAndrés Felipe Otero-RuedaAsociación Colombiana de Diabetes

Key Points

The aim is to explore the implementation of treat-to-target approaches for gout management in primary care settings.
Review of existing literature on treat-to-target urate-lowering therapy for gout.
Analysis of patient outcomes related to monosodium urate crystal dissolution.
Similar rates of monosodium urate crystal dissolution were observed in joints and tendons during urate-lowering therapy.
Complete tophus resolution was noted within 12 months on dual-energy computed tomography, representing a significant milestone.

Abstract

We read with great interest the editorial by Singh1 commenting on the study by Mulqueen et al2 that showed similar rates of monosodium urate crystal dissolution in joints and tendons during treat-to-target (T2T) urate-lowering therapy (ULT). Dr. Singh eloquently articulates the compelling pathophysiological rationale for T2T: complete tophus resolution on dual-energy computed tomography within 12 months represents "an impressive notable finding" that is "uncommon or rare in chronic medical conditions."1

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If Treat-to-Target Works for Gout, Who Will Implement It in Primary Care?

Key Points

Abstract

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