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November 1, 1995Journal of the American Society of EchocardiographyOpen Access

Age and body surface area were the most important determinants of aortic root size, yielding multivariable regression R2 values of 0.214 in men and 0.222 in women.

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Population

3,249 participants in the Framingham Heart Study and Framingham Offspring Study who were normotensive and…

Design

Cross-sectional

Key result

Age and body surface area were the most important determinants of aortic root size, yielding multivariable regression R2 values of 0.214 in men and 0.222 in women.

Authors

RVRamachandran S. VasanMLMartin G. LarsonEBEmelia J. Benjamin

Discussion

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Overview

Supports updated aortic root nomograms incorporating age and BSA; leaves open contributions from additional determinants.

Study Design

Type

Cohort (n=3,249)

Structured PICO

P
Population
3,249 participants (1,433 male and 1,816 female) in the Framingham Heart Study and Framingham Offspring Study who were normotensive and free of clinically apparent heart disease at the baseline examination.
O
Outcome
Aortic root dimensions measured by M-mode echocardiographysurrogate

This study provides sex-, age-, and body size-specific reference nomograms for M-mode echocardiographic aortic root dimensions based on a large, healthy population cohort.

Cite This Study

Vasan et al. (1995) conducted a cohort in Healthy (normotensive, free of heart disease) (n=3,249). M-mode echocardiography was evaluated on Aortic root dimensions. Age and body surface area were the most important determinants of aortic root size, yielding multivariable regression R2 values of 0.214 in men and 0.222 in women.

synapsesocial.com/papers/6a0db15ccecdf5fb20ba8fe1https://doi.org/10.1016/s0894-7317(05)80003-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Determinants of Echocardiographic Aortic Root Size1995 · 315 citations
  2. 2Transthoracic echocardiographic reference values of the aortic root: results from the Hamburg City Health Study2021 · 10 citations
  3. 3A Specific Assessment of the Normal Anatomy of the Aortic Root in Relation to Age and Gender2021 · 11 citations
  4. 4Clinical Characteristics Influence Aortic Root Dimension and Blood Flow Velocity in Healthy Subjects2001 · 8 citations
  5. 5Aortic Root Remodeling Over the Adult Life Course2010 · 183 citations