What question did this study set out to answer?

The study aims to explore the repurposing of sodium borohydride for reductive cyclization of N-(2-iodoaryl)acrylamides.

May 21, 2026Chemical Communications0 citations

Sodium Borohydride: Repurposing From Reducing Agent to Reductive Cyclization Reagent for N-(2-Iodoaryl)Acrylamides

NSNaveen SihagIndian Institute of Technology Delhi MAMini Bharati AhirwarKyoto University AKAnkit KumarIndian Institute of Technology Delhi

Key Points

The study aims to explore the repurposing of sodium borohydride for reductive cyclization of N-(2-iodoaryl)acrylamides.
Investigated the reaction of N-(2-iodoaryl)acrylamides with sodium borohydride as a cyclization reagent.
Compared the effectiveness of various hydride donors in the cyclization process.
Employed standard laboratory techniques to analyze the products formed.
Sodium borohydride successfully facilitated the formation of oxindoles from N-(2-iodoaryl)acrylamides.
Other hydride donors failed to achieve the same cyclization, highlighting sodium borohydride's unique properties.

Abstract

Herein, we report that NaBH4 facilitates an unusual reductive cyclization of N-(2-iodoaryl)acrylamide derivatives to afford oxindoles without the need for external initiators. While other hydride donors failed to achieve this...

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