What question did this study set out to answer?

The aim is to develop derivatives of (+)-usnic acid and assess their neuroprotective effects.

May 28, 2026Future Medicinal Chemistry0 citations

Novel (+)-usnic acid derivatives, computational studies and biological evaluation as neuroprotective agents

GKGautam KumarBirla Institute of Technology and Science, Pilani RKRahul KumarNational Institute of Pharmaceutical Education and Research TTanishBirla Institute of Technology and Science, Pilani

Key Points

The aim is to develop derivatives of (+)-usnic acid and assess their neuroprotective effects.
Semi-synthetic modification of (+)-usnic acid to create derivatives.
Evaluation of compounds for neuroprotective effects in scopolamine-injured C6 glial cells.
Computational studies to predict drug-likeness and binding sites of synthesized compounds.
Compounds demonstrated a decrease in NO production by binding to neuronal nitric oxide synthase.
Derivatives 6, 13, and 16 increased survival rates of scopolamine-injured C6 glial cells.

Abstract

AIMS: This study involves the semi-synthetic modification of (+)-usnic acid and the evaluation of the synthesized compounds for neuroprotective effects in scopolamine-injured C6 glial cells. MATERIALS AND METHODS: studies were conducted to predict drug-likeness and binding sites for these molecules. RESULTS: studies confirmed that these compounds decreased NO production by binding to neuronal nitric oxide synthase. CONCLUSION: Usnic acid and its derivatives, 6, 13, and 16, increased the survival of scopolamine-injured C6 glial cells.

问 AI

Bookmark

View Full Paper