Multi-omics sequencing of pig skin tissues

Key Points

• This study aims to compare cell types and gene expression in skin tissues of two pig breeds at a single-cell level.
• Used single-nucleus RNA-sequencing (snRNA-seq) and ATAC-sequencing (snATAC-seq)
• Performed bulk RNA-sequencing on skin tissues from Hezuo Tibetan pigs and Bamaxiang pigs
• Analyzed data to identify differences in gene expression and regulatory elements.
• Identified significantly different expressed genes between Hezuo Tibetan pigs and Bamaxiang pigs
• Mapped distinct regulatory elements involved in gene expression variation between the two breeds.