Two Cases of Congenital Cytomegalovirus Infection in which Treatment was Successfully Continued with G-CSF for Severe Neutropenia During Valganciclovir Therapy

Key Points

• To report on two cases of congenital cytomegalovirus infection where G-CSF facilitated treatment continuation despite severe neutropenia during valganciclovir therapy.
• Administered valganciclovir to two cases of congenital cytomegalovirus infection;
• Monitored neutrophil counts, initiating G-CSF treatment due to severe neutropenia identified at days 49 and 43, 44, 50 of life.
• Evaluated the effectiveness of G-CSF in allowing ongoing valganciclovir therapy.
• Both cases experienced neutrophil counts below 500/μL prior to G-CSF administration.
• Neutrophil counts improved shortly after initiating G-CSF, allowing continued valdanciclovir treatment.
• G-CSF was deemed useful for maintaining treatment continuity during valganciclovir-induced neutropenia.