Compared with a BMI of 25 to <30 kg/m2, mortality risk in T2DM patients was higher for both normal weight (HR 1.22; 95% CI 1.13-1.32 in men) and obese patients, showing a U-shaped association.
Cohort (n=106,640)
Does BMI category at the time of type 2 diabetes diagnosis affect mortality risk?
A U-shaped association exists between BMI and mortality in newly diagnosed type 2 diabetes, where both normal weight and severe obesity are associated with higher mortality compared to being overweight.
Hazard Ratio: 1.22 (95% CI 1.13–1.32)
OBJECTIVE: To describe the association of BMI with mortality in patients diagnosed with type 2 diabetes. RESEARCH DESIGN AND METHODS: Using records of 106,640 patients in Scotland, we investigated the association between BMI recorded around the diagnosis of type 2 diabetes mellitus (T2DM) and mortality using Cox proportional hazards regression adjusted for age and smoking status, with BMI 25 to 30 kg/m(2) by 24% (15-35%) in men and 23% (14-32%) in women, but was lower below this threshold. The results were similar after further adjustment for HbA1c, year of diagnosis, lipids, blood pressure, and socioeconomic status. CONCLUSIONS: Patients categorized as normal weight or obese with T2DM within a year of diagnosis of T2DM exhibit variably higher mortality outcomes compared with the overweight group, confirming a U-shaped association of BMI with mortality. Whether weight loss interventions reduce mortality in all T2DM patients requires study.
Logue et al. (Fri,) conducted a cohort in Type 2 diabetes mellitus (n=106,640). BMI 20 to <25 kg/m2 and ≥35 kg/m2 vs. BMI 25 to <30 kg/m2 was evaluated on Mortality (HR 1.22, 95% CI 1.13-1.32). Compared with a BMI of 25 to <30 kg/m2, mortality risk in T2DM patients was higher for both normal weight (HR 1.22; 95% CI 1.13-1.32 in men) and obese patients, showing a U-shaped association.