Key result
Compared with a BMI of 25 to <30 kg/m2, mortality risk in T2DM patients was higher for both normal weight (HR 1.22; 95% CI 1.13-1.32 in men) and obese patients, showing a U-shaped association.
Why the study?
Does BMI category at the time of type 2 diabetes diagnosis affect mortality risk?
Population
106,640 patients in Scotland diagnosed with type 2 diabetes mellitus (T2DM)
Comparison
BMI categories measured within a year after… vs BMI 25 to <30 kg/m2 as a referent group
Design
Cohort
Follow-up
Mean 4.7 years
Authors
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May guide risk stratification at T2DM diagnosis; leaves open whether BMI modification improves survival.
Cohort (n=106,640)
Does BMI category at the time of type 2 diabetes diagnosis affect mortality risk?
Hazard Ratio: 1.22 (95% CI 1.13–1.32)
A U-shaped association exists between BMI and mortality in newly diagnosed type 2 diabetes, where both normal weight and severe obesity are associated with higher mortality compared to being overweight.
Logue et al. (2012) conducted a cohort in Type 2 diabetes mellitus (n=106,640). BMI 20 to <25 kg/m2 and ≥35 kg/m2 vs. BMI 25 to <30 kg/m2 was evaluated on Mortality (HR 1.22, 95% CI 1.13-1.32). Compared with a BMI of 25 to <30 kg/m2, mortality risk in T2DM patients was higher for both normal weight (HR 1.22; 95% CI 1.13-1.32 in men) and obese patients, showing a U-shaped association.
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