Body-Mass Index and Mortality among Adults with Incident Type 2 Diabetes
Key result
Higher BMI (≥35.0 vs 22.5-24.9) was associated with increased all-cause mortality (HR 1.33; 95% CI 1.14-1.55) among adults with incident type 2 diabetes, showing no evidence of an obesity paradox.
Why the study?
Does body-mass index affect all-cause mortality in adults with incident type 2 diabetes?
Population
11,427 participants with incident type 2 diabetes who were free of cardiovascular disease and cancer at the…
Comparison
Body-mass index categories vs BMI 22.5 to 24.9 (reference category)
Design
Cohort
Follow-up
mean 15.8 years
Authors
Discussion
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Member takes
Implication
Supports weight management in incident type 2 diabetes; leaves open whether BMI reduction improves survival.
Study Design
Type
Cohort (n=11,427)
Multicenter
Yes
Structured PICO
Does body-mass index affect all-cause mortality in adults with incident type 2 diabetes?
P
Population
11,427 participants with incident type 2 diabetes, free of cardiovascular disease and cancer at diagnosis, followed for a mean of 15.8 years.
E
Exposure
Body-mass index (BMI) categories (18.5 to 22.4, 25.0 to 27.4, 27.5 to 29.9, 30.0 to 34.9, and ≥35.0)
C
Comparator
BMI 22.5 to 24.9 (reference category)
O
Outcome
All-cause mortalityhard clinical
Main Result
Hazard Ratio: 1.33 (95% CI 1.14–1.55)
Among adults with incident type 2 diabetes, there is no evidence of an obesity paradox; higher BMI is associated with increased mortality, particularly among never-smokers and those diagnosed before age 65.
Cite This Study
Tobias et al. (2014) conducted a cohort in Incident Type 2 Diabetes (n=11,427). Body-mass index (BMI) vs. BMI 22.5 to 24.9 was evaluated on All-cause mortality (HR 1.33, 95% CI 1.14 to 1.55). Higher BMI (≥35.0 vs 22.5-24.9) was associated with increased all-cause mortality (HR 1.33; 95% CI 1.14-1.55) among adults with incident type 2 diabetes, showing no evidence of an obesity paradox.