A 1-year delay in age at menarche was associated with a 4.5% lower total mortality (95% CI 2.3-6.7), as well as lower mortality from ischaemic heart disease and stroke.
Cohort (n=19,462)
Is age at menarche associated with total mortality and mortality from ischaemic heart disease and stroke in women?
Early menarche is associated with increased total, ischaemic heart disease, and stroke mortality in women.
Effect estimate: 4.5% lower (95% CI 2.3-6.7)
p-value: p=<0.001
BACKGROUND: Little is known about the relationship between age at menarche and total mortality and mortality from ischaemic heart disease and stroke. METHODS: A cohort study of 19 462 Californian Seventh-Day Adventist women followed-up from 1976 to 1988. A total of 3313 deaths occurred during follow-up, of which 809 were due to ischaemic heart disease and 378 due to stroke. RESULTS: An early menarche was associated with increased total mortality (P-value for linear trend <0.001), ischaemic heart disease (P-value for linear trend = 0.01) and stroke (P-value for linear trend = 0.02) mortality. There were, however, also some indications of an increased ischaemic heart disease mortality in women aged 16-18 at menarche (5% of the women). When assessed as a linear relationship, a 1-year delay in menarche was associated with 4.5% (95% CI 2.3-6.7) lower total mortality. The association was stronger for ischaemic heart disease 6.0% (95% CI 1.2-10.6) and stroke 8.6% (95% CI 1.6-15.1) mortality. CONCLUSIONS: The results suggest that there is a linear, inverse relationship between age at menarche and total mortality as well as with ischaemic heart disease and stroke mortality.
Jacobsen et al. (Sun,) reported a cohort. Age at menarche was evaluated on Total mortality (4.5% lower, 95% CI 2.3-6.7, p=<0.001). A 1-year delay in age at menarche was associated with a 4.5% lower total mortality (95% CI 2.3-6.7), as well as lower mortality from ischaemic heart disease and stroke.