Key result
A 1-year delay in age at menarche was associated with a 4.5% lower total mortality (95% CI 2.3-6.7), as well as lower mortality from ischaemic heart disease and stroke.
Why the study?
Is age at menarche associated with total mortality and mortality from ischaemic heart disease and stroke in women?
Population
19,462 Californian Seventh-Day Adventist women
Design
Cohort
Follow-up
1976 to 1988
Authors
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May refine mortality risk stratification via reproductive history; leaves open causality and intervention potential.
Cohort (n=19,462)
Is age at menarche associated with total mortality and mortality from ischaemic heart disease and stroke in women?
Effect estimate: 4.5% lower (95% CI 2.3-6.7)
p-value: p=<0.001
Early menarche is associated with increased total, ischaemic heart disease, and stroke mortality in women.
Jacobsen et al. (2009) reported a cohort. Age at menarche was evaluated on Total mortality (4.5% lower, 95% CI 2.3-6.7, p=<0.001). A 1-year delay in age at menarche was associated with a 4.5% lower total mortality (95% CI 2.3-6.7), as well as lower mortality from ischaemic heart disease and stroke.
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