November 1, 1987American Journal of Epidemiology
A Prospective Study of Age at Menarche, Parity, Age at First Birth, and Coronary Heart Disease in Women
Why the study?
Do reproductive events (age at menarche, parity, age at first birth) influence the risk of coronary heart disease in women?
Population
119,963 US women aged 30-55 years who were free from coronary heart disease in 1976
Comparison
Reproductive events vs Different categories of reproductive events
Design
Cohort
Follow-up
1976 through 1982 (700,809 person-years)
Authors
Discussion
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Implication
Null associations with parity and age at first birth warrant no change in CHD risk assessment; leaves open questions for larger prospective cohorts.
Structured PICO
Do reproductive events (age at menarche, parity, age at first birth) influence the risk of coronary heart disease in women?
P
Population
119,963 US women aged 30-55 years who were free from coronary heart disease in 1976
I
Intervention
Reproductive events (age at menarche, parity, age at first birth)
C
Comparator
Different categories of reproductive events (e.g., menarche at age 13, parous women)
O
Outcome
Incident cases of nonfatal myocardial infarction or fatal coronary heart diseasehard clinical
Reproductive experiences such as age at menarche, parity, and age at first birth do not have an important association with the risk of coronary heart disease in women.
Cite This Study
Colditz et al. (1987) studied this question.