July 1, 1984American Journal of Epidemiology
Reproductive History in Women With Coronary Heart Disease: A Case-Control Study
Why the study?
Are reproductive history events associated with an increased risk of coronary heart disease in women under age 60?
Population
507 women under age 60, comprising 169 cases with a diagnosis of coronary heart disease and 338 age- and…
Comparison
Reproductive history events, specifically… vs Absence of these reproductive history events.
Design
Case-control
Authors
Discussion
Loading...
Member takes
Implication
Early first pregnancy associated with higher CHD risk under 60; leaves open whether reproductive history should inform screening or prevention.
Structured PICO
Are reproductive history events associated with an increased risk of coronary heart disease in women under age 60?
P
Population
507 women under age 60, comprising 169 cases with a diagnosis of coronary heart disease (angina n=95, myocardial infarction n=59, sudden unexpected death n=15) and 338 age- and sex-matched controls from Rochester, Minnesota.
I
Intervention
Reproductive history events, specifically artificial menopause and age at first pregnancy < 25 years.
C
Comparator
Absence of these reproductive history events (e.g., never pregnant or age at first pregnancy ≥ 25 years).
O
Outcome
Diagnosis of coronary heart disease.hard clinical
Early age at first pregnancy (<25 years) and artificial menopause are associated with an increased risk of coronary heart disease in women under age 60, independent of traditional cardiovascular risk factors.
Cite This Study
Beard et al. (1984) studied this question.