Key result
First childbirth under age 20 linked to ~32% higher later-life maternal CVD risk versus ages 25-29.
Why the study?
The study was conducted to examine the associations of parity and age at childbirth with maternal cardiovascular disease.
Does young age at first childbirth increase incident CVD events in postmenopausal women without existing CVD?
Cohort
Does young age at first childbirth increase incident CVD events in postmenopausal women without existing CVD?
Effect estimate: HR 1.32 (95% CI 1.22-1.44)
Young age at first childbirth (<25 years) is associated with an increased risk of later-life maternal cardiovascular disease in postmenopausal women, potentially mediated by premature menopause and hypertension.
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May inform CVD risk stratification via reproductive history; hypothesis-generating and requires prospective confirmation before clinical adoption.
Xing et al. (2025) conducted a cohort in Cardiovascular disease. Age at first childbirth <20 years vs. Age at first childbirth 25-29 years was evaluated on Incident cardiovascular disease events (initial occurrence of coronary heart disease, heart failure, ischemic stroke, or death due to these conditions) (HR 1.32, 95% CI 1.22-1.44). Age at first childbirth younger than 20 years was associated with an increased risk of later-life maternal cardiovascular disease compared to age 25-29 years (HR 1.32; 95% CI 1.22-1.44).
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