Key result
Maternal age at first delivery of 25 years or less was associated with a higher risk of myocardial infarction compared to ages 31-35 years (OR 4.82; 95% CI 1.39-16.75).
Why the study?
Does younger maternal age at first delivery increase the risk of cardiovascular disease later in life in women?
Cross-Sectional (n=3,937)
Does younger maternal age at first delivery increase the risk of cardiovascular disease later in life in women?
Odds Ratio: 4.82 (95% CI 1.39–16.75)
Younger maternal age at first delivery (≤25 years) is associated with a significantly increased risk of subsequent cardiovascular disease, particularly myocardial infarction.
Should not yet inform clinical risk assessment; leaves open whether early first delivery contributes to later MI risk in women.
Background. To elucidate the association between maternal age at first delivery and cardiovascular health in women. Material and Method. A nationally representative survey, comprising 3,937 Finnish women aged 30–99 years with information on most of the potential cardiovascular disease (CVD) risk factors. Weighting survey analyses and logistic regression were performed. Results. Women who had their first delivery at age 25 or less had about five times higher odds ratio for myocardial infarction (fully adjusted OR: 4.82; 95% CI: 1.39–16.75) and about 2-fold higher odds ratio of arrhythmia (fully adjusted OR: 1.82; 95% CI: 1.13–2.92) compared to those who were 31–35 years at their first delivery. Each one year younger maternal age at first delivery predicted a higher risk of myocardial infarction (age-adjusted ; 95% CI: 1.06–1.18), hypertension (age-adjusted ; 95% CI: 1.03–1.07), arrhythmia (age-adjusted OR = 1.03; 95% CI: 1.01–1.05), angina pectoris (age-adjusted OR = 1.06; 95% CI: 1.02–1.10), and heart failure (age-adjusted ; 95% CI: 1.01–1.10). Conclusion. Maternal earlier age at first delivery is related to subsequent development of CVD, especially myocardial infarction. Our findings suggest a need for additional care and monitoring for CVD and its risk factors in women who had their first delivery at young ages.
No takes yet. Share an insight, caveat, or question.
Kharazmi et al. (2013) conducted a cross-sectional in Cardiovascular disease (n=3,937). Maternal age at first delivery ≤25 years vs. Maternal age at first delivery 31-35 years was evaluated on Myocardial infarction (OR 4.82, 95% CI 1.39-16.75). Maternal age at first delivery of 25 years or less was associated with a higher risk of myocardial infarction compared to ages 31-35 years (OR 4.82; 95% CI 1.39-16.75).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: