June 11, 2010Stroke
Childbearing, Child-Rearing, Cardiovascular Risk Factors, and Progression of Carotid Intima-Media Thickness
Key result
Childbirth in females over a 6-year period was associated with increased progression of carotid intima-media thickness (7.5+/-3.2 μm/birth, P=0.02) independent of traditional risk factors.
Why the study?
Does childbearing increase the progression of carotid intima-media thickness and alter cardiovascular risk factors in women of reproductive age?
Population
1,786 subjects of reproductive age from the Cardiovascular Risk in Young Finns study
Comparison
Childbirth/childbearing during a 6-year period vs Males and females with fewer or no childbirths
Design
Cohort
Follow-up
6 years
Authors
Discussion
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Implication
May accelerate subclinical atherosclerosis after childbirth; leaves open effects on clinical events and need for targeted prevention.
Study Design
Type
Cohort (n=1,786)
Structured PICO
Does childbearing increase the progression of carotid intima-media thickness and alter cardiovascular risk factors in women of reproductive age?
P
Population
1,786 men and women of reproductive age from the Cardiovascular Risk in Young Finns study followed for 6 years.
E
Exposure
Childbirth/childbearing during a 6-year period
C
Comparator
Males (exposed to child-rearing but not biological childbearing) and females with fewer or no childbirths
O
Outcome
Progression of carotid intima-media thickness over a 6-year periodsurrogate
Main Result
p-value: p=0.02
Childbearing is associated with accelerated progression of preclinical carotid atherosclerosis and adverse changes in lipid profiles in women, independent of traditional risk factors.
Cite This Study
Skilton et al. (2010) conducted a cohort in Cardiovascular risk (n=1,786). Childbearing vs. Males (exposed to child-rearing but not childbearing) was evaluated on Progression of carotid intima-media thickness (p=0.02). Childbirth in females over a 6-year period was associated with increased progression of carotid intima-media thickness (7.5+/-3.2 μm/birth, P=0.02) independent of traditional risk factors.