Key result
A history of stillbirth was associated with an increased age-adjusted risk of carotid plaque (OR 3.43; 95% CI 1.07-11.05), which lost statistical significance after full adjustment.
Why the study?
Is reproductive history associated with subclinical atherosclerosis (carotid intima-media thickness and plaque) in women aged 45-74 years?
Population
746 Finnish women, aged 45-74 years, from a population-based cross-sectional study.
Comparison
Reproductive history assessed by questionnaire. vs Women without the specific reproductive history.
Design
Cross-sectional
Authors
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Should not yet alter CV risk assessment in women with prior stillbirth; leaves open an independent association with carotid plaque.
Cross-Sectional (n=746)
Is reproductive history associated with subclinical atherosclerosis (carotid intima-media thickness and plaque) in women aged 45-74 years?
Odds Ratio: 3.61 (95% CI 0.86–15.23)
Certain reproductive history factors, such as stillbirth, may be associated with preclinical atherosclerosis, though these associations are heavily confounded by age and other metabolic risk factors.
Kharazmi et al. (2007) conducted a cross-sectional in Preclinical atherosclerosis (n=746). History of stillbirth vs. No history of stillbirth was evaluated on Carotid plaque (OR 3.61, 95% CI 0.86-15.23). A history of stillbirth was associated with an increased age-adjusted risk of carotid plaque (OR 3.43; 95% CI 1.07-11.05), which lost statistical significance after full adjustment.
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