The autophagy-inhibitory tissue hormone DBI/ACBP contributes to the pathogenesis of multiple organ dysfunction syndrome in septic shock

Key Points

• The research aims to elucidate the role of DBI/ACBP in the pathogenesis of organ dysfunction during septic shock.
• Examined models of monomicrobial and polymicrobial sepsis to assess the effects of DBI/ACBP.
• Analyzed its anti-autophagic, immunosuppressive, pro-inflammatory, and pro-senescent properties.
• DBI/ACBP was identified as a pathogenic mediator of sepsis.
• It was linked to increased inflammation and organ dysfunction.