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January 1, 1974Diabetes

Plasma Norepinephrine and Epinephrine in Untreated Diabetics, During Fasting and After Insulin Administration

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Why the study?

How do plasma norepinephrine and epinephrine levels change in diabetics compared to normal subjects under various metabolic conditions and insulin administration?

Population

23 normal subjects and 14 diabetics

Comparison

Various metabolic conditions including fasting… vs Normal subjects versus diabetics, and…

Design

Other

Authors

NCNiels Juel Christensen

Discussion

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Overview

May prompt accounting for glycemic control when interpreting catecholamine levels; leaves open causal and therapeutic implications.

Structured PICO

How do plasma norepinephrine and epinephrine levels change in diabetics compared to normal subjects under various metabolic conditions and insulin administration?

P
Population
23 normal subjects and 14 diabetics
I
Intervention
Various metabolic conditions including fasting, exercise, and insulin administration
C
Comparator
Normal subjects versus diabetics, and comparisons across different metabolic states
O
Outcome
Plasma norepinephrine and epinephrine levelssurrogate

Plasma catecholamine levels are elevated in poorly controlled diabetes and ketosis, but normalize with adequate insulin treatment.

Cite This Study

Niels Juel Christensen (1974) studied this question.

synapsesocial.com/papers/6a226a33b65eef78bdff5f66https://doi.org/10.2337/diab.23.1.1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma Epinephrine Disturbances in Diabetic Subjects during Standing and after Isometric Exercise*1981 · 14 citations
  2. 2Blood Ketone Response to Norepinephrine-induced Free Fatty Acid Elevation in Diabetes1964 · 9 citations
  3. 3Decreased Response of Epinephrine and Norepinephrine to Insulin-Induced Hypoglycemia in Diabetic Autonomic Neuropathy1984 · 23 citations
  4. 4Correlation of Norepinephrine with some biochemical Parametric in Patients with type 2 diabetes mellitus.2023
  5. 5Metabolic and Cardiovascular Responses to Epinephrine in Diabetic Autonomic Neuropathy1987 · 65 citations