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July 1, 1994Journal of Biological ChemistryOpen Access

Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger

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Population

Rat brain cDNA library and Xenopus oocytes

Comparison

Cloning and expression of the NCX2 isoform of… vs NCX1 isoform

Design

Preclinical

Authors

ZLZhigui LiSMSatoshi MatsuokaLHLarry V. Hryshko

Discussion

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Overview

NCX2's distinct properties suggest tissue-specific calcium handling; leaves open its relevance to human cardiac or neurological disease.

Structured PICO

P
Population
Rat brain cDNA library and Xenopus oocytes
I
Intervention
Cloning and expression of the NCX2 isoform of the Na(+)-Ca2+ exchanger
C
Comparator
NCX1 isoform
O
Outcome
Electrophysiological properties and sequence characteristics of NCX2surrogate

The cloning of the NCX2 isoform reveals a second Na(+)-Ca2+ exchanger with distinct regulatory properties, suggesting functional flexibility in cellular calcium regulation.

Cite This Study

Li et al. (1994) studied this question.

synapsesocial.com/papers/6a22b0ff80ebe3feac149ef7https://doi.org/10.1016/s0021-9258(17)32458-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cloning of a Third Mammalian Na+-Ca2+ Exchanger, NCX31996 · 348 citations
  2. 2Functional comparison of the three isoforms of the Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX1, NCX2, NCX3)1998 · 231 citations
  3. 3Molecular Biological Studies of the Cardiac Sodium‐Calcium Exchanger<sup>a</sup>1996 · 15 citations
  4. 4K+‐Dependent Na+/Ca2+ Exchangers in the Brain2002 · 67 citations
  5. 5Tissue specificity and alternative splicing of the Na+/Ca2+ exchanger isoforms NCX1, NCX2, and NCX3 in rat1997 · 414 citations