Population
BHK cells stably expressing mammalian Na+/Ca2+ exchangers (NCX1, NCX2, NCX3)
Comparison
Expression of NCX1, NCX2, or NCX3 vs Comparison among the three isoforms
Design
Preclinical
Key result
The three mammalian Na+/Ca2+ exchanger isoforms (NCX1, NCX2, and NCX3) exhibited markedly similar apparent affinities for Na+ and Ca2+ and generally similar responses to pH and inhibitors.
Authors
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Basic NCX isoform comparison in cell models advances molecular insights; leaves open differential cardiac roles pending in vivo validation.
The three mammalian Na+/Ca2+ exchanger isoforms (NCX1, NCX2, NCX3) exhibit highly similar functional properties when expressed in BHK cells, with minor differences in ATP sensitivity.
Linck et al. (1998) studied this question. Na+/Ca2+ exchanger isoforms (NCX1, NCX2, NCX3) was evaluated on Na+/Ca2+ exchange activity. The three mammalian Na+/Ca2+ exchanger isoforms (NCX1, NCX2, and NCX3) exhibited markedly similar apparent affinities for Na+ and Ca2+ and generally similar responses to pH and inhibitors.