Differential inhibition of Na⁺/Ca²⁺exchanger isoforms by divalent cations and isothiourea derivative

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Population

CCL-39 (Dede) fibroblasts stably expressing mammalian Na+/Ca2+ exchanger isoforms NCX1, NCX2, and NCX3

Design

Preclinical

Authors

Discussion

May inform isoform-selective NCX inhibitor development; leaves open human translation.

Population

CCL-39 (Dede) fibroblasts stably expressing mammalian Na+/Ca2+ exchanger isoforms NCX1, NCX2, and NCX3

Intervention

Divalent cations (Ni2+, Co2+, La3+, Cd2+), monovalent cation Li+, and isothiourea derivative KB-R7943

Outcome

Intracellular Na+-dependent 45Ca2+ uptakesurrogate

Distinct kinetic and pharmacological differences exist between the NCX3 isoform and the NCX1/NCX2 isoforms of the Na+/Ca2+ exchanger.

Iwamoto et al. (1998) studied this question.

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