NT-proBNP levels ≥615 pg/ml at day 2 after symptom onset were associated with 6-month mortality in patients with acute ischemic stroke.
Cohort (n=250)
Does the level of NT-proBNP after acute ischemic stroke predict 6-month mortality?
NT-proBNP peaks the day after acute ischemic stroke, and a single measurement at day 2 serves as a prognostic indicator for 6-month mortality.
BACKGROUND: The exact time-course of N-terminal pro-brain natriuretic peptide (NT-proBNP) and the prognostic importance in the immediate phase of ischemic stroke have not been established. METHODS: NT-proBNP was measured daily from admission to day 5 and again at 6-month follow-up in 250 consecutive patients with acute ischemic stroke. RESULTS: NT-proBNP peaked the day after onset of symptoms (p = 0.007) followed by a decrease until day 5 (p = 0.001, ANOVA). At 6-month follow-up the difference in the level of NT-proBNP was unchanged compared to day 5 (p = 0.42). NT-proBNP levels > or =615 pg/ml at day 2 after onset of symptoms was associated with 6-month mortality. CONCLUSION: NT-proBNP peaks the day after onset of symptoms in patients with acute ischemic stroke. A single measurement of NT-proBNP appears to be an indicator of 6-month mortality.
Jensen et al. (Sun,) conducted a cohort in Acute ischemic stroke (n=250). NT-proBNP levels was evaluated on 6-month mortality. NT-proBNP levels ≥615 pg/ml at day 2 after symptom onset were associated with 6-month mortality in patients with acute ischemic stroke.
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