What is the clinical evidence from this study?

Study design: Cohort. Population: Acute ischemic stroke (n=250). Intervention: NT-proBNP levels. Primary outcome: 6-month mortality.

What question did this study set out to answer?

This research aims to establish the time-course and prognostic importance of NT-proBNP after acute ischemic stroke.

January 1, 2006Cerebrovascular Diseases

Serial Measurements of N-Terminal pro-Brain Natriuretic Peptide after Acute Ischemic Stroke

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Key result

NT-proBNP levels ≥615 pg/ml at day 2 after symptom onset were associated with 6-month mortality in patients with acute ischemic stroke.

Why the study?

Does the level of NT-proBNP after acute ischemic stroke predict 6-month mortality?

Population

250 consecutive patients with acute ischemic stroke

Design

Cohort

Follow-up

6 months

Authors

JJJesper K. JensenAarhus University Hospital HMHans MickleyCardiac Imaging SBS. BąkDartmouth College

Discussion

Member takes

Implication

Day-2 NT-proBNP ≥615 pg/ml may aid mortality risk stratification after ischemic stroke; hypothesis-generating pending prospective validation.

Key Points

This research aims to establish the time-course and prognostic importance of NT-proBNP after acute ischemic stroke.
NT-proBNP was measured daily from admission to day 5 and again at 6-month follow-up in 250 consecutive patients with acute ischemic stroke.
NT-proBNP peaked the day after symptom onset (p = 0.007) and decreased until day 5 (p = 0.001).
At 6-month follow-up, NT-proBNP levels remained unchanged from day 5 (p = 0.42).
NT-proBNP levels >615 pg/ml on day 2 were associated with increased 6-month mortality.

Study Design

Type

Cohort (n=250)

Structured PICO

Does the level of NT-proBNP after acute ischemic stroke predict 6-month mortality?

Population

250 consecutive patients with acute ischemic stroke, with NT-proBNP measured daily up to day 5 and at 6-month follow-up.

Exposure

Serial measurements of NT-proBNP daily from admission to day 5 and at 6-month follow-up

Outcome

Time-course of NT-proBNP levels and 6-month mortalityhard clinical

NT-proBNP peaks the day after acute ischemic stroke, and a single measurement at day 2 serves as a prognostic indicator for 6-month mortality.

Cite This Study

Jensen et al. (2006) conducted a cohort in Acute ischemic stroke (n=250). NT-proBNP levels was evaluated on 6-month mortality. NT-proBNP levels ≥615 pg/ml at day 2 after symptom onset were associated with 6-month mortality in patients with acute ischemic stroke.

synapsesocial.com/papers/6a33015dc832e26dfd08bf8f https://doi.org/10.1159/000094997

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Implication

Day-2 NT-proBNP ≥615 pg/ml may aid mortality risk stratification after ischemic stroke; hypothesis-generating pending prospective validation.

Serial Measurements of N-Terminal pro-Brain Natriuretic Peptide after Acute Ischemic Stroke

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Serial Measurements of N-Terminal pro-Brain Natriuretic Peptide after Acute Ischemic Stroke

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider