Key result
Baseline NT-proBNP concentration >1330 pg/mL on admission was an independent predictor of short-term mortality within 1 week after acute ischemic stroke (P=0.03).
Why the study?
Does baseline NT-proBNP level on admission predict short-term mortality in patients with acute ischemic stroke?
Observational (n=100)
Does baseline NT-proBNP level on admission predict short-term mortality in patients with acute ischemic stroke?
p-value: p=.03
Elevated baseline NT-proBNP levels on admission independently predict short-term (1-week) mortality in patients with acute ischemic stroke.
May aid short-term risk stratification after ischemic stroke; hypothesis-generating and requires prospective validation.
N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are frequently elevated in patients with acute ischemic stroke. This study investigated whether the baseline NT-proBNP level on admission can predict short-term mortality after ischemic stroke. One hundred patients with acute ischemic stroke underwent thorough clinical and laboratory evaluation, including serum NT-proBNP measurement. A total of 7% of patients died within 1 week after stroke onset. The NT-proBNP levels were significantly higher among the patients who died compared to NT-proBNP levels in the survivors (P = .002). The optimal NT-proBNP cut-off point for predicting mortality was 1330 pg/mL. Multivariate analysis demonstrated that NT-proBNP concentration was an independent predictor of short-term post-stroke mortality (P = .03). Increased NT-proBNP level was significantly and independently correlated with short-term mortality in patients after ischemic stroke.
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Ghabaee et al. (2013) conducted an observational in Acute ischemic stroke (n=100). Baseline NT-proBNP level was evaluated on Short-term mortality (p=.03). Baseline NT-proBNP concentration >1330 pg/mL on admission was an independent predictor of short-term mortality within 1 week after acute ischemic stroke (P=0.03).
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