马达加斯加cVDPV分离株中存在的HEV-C序列有助于其特征,包括致病性,提示跨种重组有利于cVDPV的出现。
其他
与HEV-C序列的跨种重组有助于疫苗衍生脊髓灰质炎病毒的致病性和表型生物多样性。
致病性循环疫苗衍生脊髓灰质炎病毒(cVDPVs)已成为全球脊髓灰质炎根除计划成功完成的主要障碍。大多数cVDPVs是在口服脊髓灰质炎疫苗(OPV)和人类肠病毒C型(HEV-C)之间的重组。为研究HEV-C序列在cVDPVs表型中的作用,我们在一株来自马达加斯加的cVDPV分离株和其母株OPV 2型之间生成了一系列重组体。结果表明,此cVDPV中存在的HEV-C序列有助于其特征,包括致病性,提示跨种重组有助于脊髓灰质炎病毒的表型生物多样性,并可能促进cVDPVs的出现。
Riquet et al. (Thu,) conducted a other in Circulating vaccine-derived polioviruses (cVDPVs). HEV-C sequences in cVDPV recombinants vs. Parental OPV type 2 strain was evaluated on Phenotype and pathogenicity characteristics. HEV-C sequences present in the Madagascar cVDPV isolate contribute to its characteristics, including pathogenicity, suggesting interspecific recombination favors cVDPV emergence.
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