Key points are not available for this paper at this time.
Abstract Styrenes represent a challenging class of substrates for current radical trifluoromethylation and hydrotrifluoromethylation methods due to a myriad of potential side reactions. Herein, we describe the development of mild, selective and broadly applicable photocatalytic trifluoromethylation and hydrotrifluoromethylation protocols for these challenging substrates. The methods use fac‐Ir(ppy) 3 , visible light and inexpensive CF 3 I and can be applied to a diverse set of vinylarene substrates. The use of continuous‐flow photochemical reaction conditions allowed to reduce the reaction time and increase the reaction selectivity.
Straathof et al. (Tue,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: