High supplementary vitamin E intake (≥100 IU/day) was associated with less carotid intima-media thickness progression compared to low intake in subjects on placebo (0.008 vs 0.023 mm/y, P=0.03).
Observational (n=146)
Does supplementary antioxidant vitamin intake reduce the progression of carotid intima-media thickness in nonsmoking men with previous CABG?
Supplementary vitamin E intake may reduce the progression of early atherosclerosis in patients not treated with lipid-lowering drugs.
Absolute Event Rate: 0.008% vs 0.023%
p-value: p=0.03
BACKGROUND: There is accumulating experimental, epidemiological, and clinical evidence of an association between anti-oxidant vitamin intake and reduced risk of coronary heart disease. Using data from the Cholesterol Lowering Atherosclerosis Study (CLAS), we explored the association of self-selected supplementary antioxidant vitamin intake on the rate of progression of early preintrusive atherosclerosis. METHODS AND RESULTS: CLAS was an arterial imaging trial in which nonsmoking 40- to 59-year-old men with previous coronary artery bypass graft surgery were randomized to colestipol/niacin plus diet or placebo plus diet. The rate of progression of early preintrusive atherosclerosis was determined in 146 subjects using high-resolution B-mode ultrasound quantification of the distal common carotid artery far wall intima-media thickness (IMT). From the nutritional supplement database, 22 subjects had an on-trial average supplementary vitamin E intake of > or = 100 IU per day (high users) and 29 subjects had an average on-trial supplementary vitamin C intake of > or = 250 mg per day (high users). Within the placebo group, less carotid IMT progression was found for high supplementary vitamin E users when compared with low vitamin E users (0.008 versus 0.023 mm/y, P = .03). No effect of vitamin E within the drug group was found. No effect of vitamin C within the drug or placebo group was found. CONCLUSIONS: Supplementary vitamin E intake appears to be effective in reducing the progression of atherosclerosis in subjects not treated with lipid-lowering drugs while the process is still confined to the arterial wall (early preintrusive atherosclerosis).
Azen et al. (Fri,) conducted a observational in Early preintrusive atherosclerosis (n=146). Supplementary vitamin E intake vs. Low vitamin E users was evaluated on Rate of progression of early preintrusive atherosclerosis (carotid intima-media thickness) (p=0.03). High supplementary vitamin E intake (≥100 IU/day) was associated with less carotid intima-media thickness progression compared to low intake in subjects on placebo (0.008 vs 0.023 mm/y, P=0.03).