Key result
High supplementary vitamin E intake (≥100 IU/day) was associated with less carotid intima-media thickness progression compared to low intake in subjects on placebo (0.008 vs 0.023 mm/y, P=0.03).
Why the study?
Does supplementary antioxidant vitamin intake reduce the progression of carotid intima-media thickness in nonsmoking men with previous CABG?
Population
146 nonsmoking 40- to 59-year-old men with previous coronary artery bypass graft surgery
Comparison
Self-selected supplementary vitamin E or vitamin C vs Low supplementary vitamin E or vitamin C users
Design
Cohort, Main trial randomized to colestipol/niacin plus diet or placebo plus…
Authors
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Supports hypothesis of vitamin E slowing atherosclerosis in untreated CABG patients; hypothesis-generating and should not change practice.
Observational (n=146)
Does supplementary antioxidant vitamin intake reduce the progression of carotid intima-media thickness in nonsmoking men with previous CABG?
Absolute Event Rate: 0.008% vs 0.023%
p-value: p=0.03
Supplementary vitamin E intake may reduce the progression of early atherosclerosis in patients not treated with lipid-lowering drugs.
Azen et al. (1996) conducted an observational in Early preintrusive atherosclerosis (n=146). Supplementary vitamin E intake vs. Low vitamin E users was evaluated on Rate of progression of early preintrusive atherosclerosis (carotid intima-media thickness) (p=0.03). High supplementary vitamin E intake (≥100 IU/day) was associated with less carotid intima-media thickness progression compared to low intake in subjects on placebo (0.008 vs 0.023 mm/y, P=0.03).
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