The Melbourne Atherosclerosis Vitamin E Trial (MAVET): a study of high dose vitamin E in smokers
Key result
Vitamin E supplementation did not significantly reduce carotid intima-media thickness progression compared to placebo in chronic smokers over 4 years (MD 0.0041 mm/year; P=0.20).
Why the study?
Does natural vitamin E 500 IU per day reduce the progression of carotid atherosclerosis in chronic smokers aged 55 years and over?
Population
409 male and female chronic smokers aged 55 years and over
Comparison
Natural vitamin E 500 IU per day for 4 years vs Placebo
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
4 years
Authors
Discussion
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Implication
Does not support vitamin E to slow carotid atherosclerosis in smokers; challenges translation of LDL oxidation reduction into vascular benefit.
Study Design
Type
RCT (n=409)
Blinding
Double-blind
Randomization
randomized
Structured PICO
Does natural vitamin E 500 IU per day reduce the progression of carotid atherosclerosis in chronic smokers aged 55 years and over?
P
Population
409 male and female chronic smokers aged 55 years and over, followed for 4 years.
I
Intervention
Natural vitamin E 500 IU per day for 4 years
C
Comparator
Placebo
O
Outcome
Progression of carotid atherosclerosis determined by intima-media thickness of the right common carotid artery over 4 yearssurrogate
Main Result
Mean Difference: 0.0041 (95% CI -0.0021–0.0102)
p-value: p=0.20
High-dose vitamin E supplementation does not slow the progression of carotid atherosclerosis in chronic smokers, despite reducing LDL oxidative susceptibility.
Cite This Study
Magliano et al. (2006) conducted an RCT in chronic smokers (n=409). vitamin E vs. placebo was evaluated on progression of carotid atherosclerosis determined by intima-media thickness of the right common carotid artery (MD 0.0041, 95% CI -0.0021 to 0.0102, p=0.20). Vitamin E supplementation did not significantly reduce carotid intima-media thickness progression compared to placebo in chronic smokers over 4 years (MD 0.0041 mm/year; P=0.20).