Food supplementation with 1000 mg/day of olive leaf extract EFLA943 significantly reduced systolic blood pressure (mean difference ≤13 mmHg vs 500 mg/day) in borderline hypertensive twins.
RCT (n=40)
Open-label
Does olive leaf extract EFLA943 reduce blood pressure in borderline hypertensive monozygotic twins?
High-dose olive leaf extract (1000 mg/day) significantly reduces blood pressure and LDL-cholesterol in borderline hypertensive individuals.
Effect estimate: mean systolic difference ≤13 mmHg (1000 vs 500 mg)
Hypertension is a harmful disease factor that develops unnoticed over time. The treatment of hypertension is aimed at an early diagnosis followed by adequate lifestyle changes rather than pharmacological treatment. The olive leaf extract EFLA943, having antihypertensive actions in rats, was tested as a food supplement in an open study including 40 borderline hypertensive monozygotic twins. Twins of each pair were assigned to different groups receiving 500 or 1000 mg/day EFLA943 for 8 weeks, or advice on a favourable lifestyle. Body weight, heart rate, blood pressure, glucose and lipids were measured fortnightly. Blood pressure changed significantly within pairs, depending on the dose, with mean systolic differences of < or =6 mmHg (500 mg vs control) and < or =13 mmHg (1000 vs 500 mg), and diastolic differences of < or =5 mmHg. After 8 weeks, mean blood pressure remained unchanged from baseline in controls (systolic/diastolic: 133 +/- 5/77 +/- 6 vs 135 +/- 11/80 +/- 7 mmHg) and the low-dose group (136 +/- 7/77 +/- 7 vs 133 +/- 10/76 +/- 7), but had significantly decreased for the high dose group (137 +/- 10/80 +/- 10 vs 126 +/- 9/76 +/- 6). Cholesterol levels decreased for all treatments with significant dose-dependent within-pair differences for LDL-cholesterol. None of the other parameters showed significant changes or consistent trends. Concluding, the study confirmed the antihypertensive and cholesterol-lowering action of EFLA943 in humans.
Perrinjaquet-Moccetti et al. (Wed,) conducted a rct in Borderline hypertension (n=40). Olive leaf extract EFLA943 vs. Advice on a favourable lifestyle was evaluated on Blood pressure (mean systolic difference ≤13 mmHg (1000 vs 500 mg)). Food supplementation with 1000 mg/day of olive leaf extract EFLA943 significantly reduced systolic blood pressure (mean difference ≤13 mmHg vs 500 mg/day) in borderline hypertensive twins.