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Ventricles of 21 patients with coronary artery disease examined by coronary angiography and left ventriculography were studied histologically. The amount of fibrosis was compared to the decrease in function indicated by ventriculography, elevation of left ventricular end diastolic pressure (LVEDP), and reduction of ejection fraction. In 51% of ventricular segments dysfunction paralleled the presence or absence of fibrosis. In 42%, dysfunction, more severe than the fibrosis, was due to ischemia or coronary steal. Patchy fibrosis in 7% did not significantly decrease function. Severe decrease in ejection fraction and elevation of LVEDP may be due to ischemia not fibrosis.
Baltaxe et al. (Sun,) studied this question.