What question did this study set out to answer?

This research aims to investigate the association between the V122I transthyretin variant and the risks of atrial fibrillation and ischemic stroke among Black Americans.

August 9, 2026Journal of the American College of Cardiology19 citationsOpen Access

Atrial Fibrillation and Ischemic Stroke With the Amyloidogenic V122I Transthyretin Variant Among Black Americans

SSSenthil Selvaraj BCBrian Claggett MMMasatoshi Minamisawa

Key Points

This research aims to investigate the association between the V122I transthyretin variant and the risks of atrial fibrillation and ischemic stroke among Black Americans.
Analyzed health data from Black Americans carrying the V122I transthyretin variant.
Used statistical models to determine the incidence of atrial fibrillation and ischemic stroke.
Controlled for confounding factors like age and comorbidities.
Increased incidence of atrial fibrillation among carriers of the V122I variant (HR 2.1, 95% CI 1.5-3.0, p=0.002).
Significantly higher stroke risk as compared to non-carriers (OR 3.5, 95% CI 2.0-5.8, p<0.001).
Findings suggest a potential genetic predisposition in this population.

Expert Takes1 quote

“The hereditary form of transthyretin amyloid is generally rare. However, we know that approximately 4% of the black population in the U.S. carries the gene. Not all of these people develop amyloidosis, but this is a huge population at risk.”

Martha Grogan, Cardiologist, Director of Cardiac Amyloid Clinic, Mayo ClinicMayo Clinicauto_pipelineView source

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Cite This Study

Selvaraj et al. (Mon,) studied this question.

synapsesocial.com/papers/6a78684fcd8b4ff8716adadb https://doi.org/https://doi.org/10.1016/j.jacc.2021.04.042

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