Intracoronary Low-Dose Thrombolysis in Primary PCI for STEMI: A Systematic Review and Meta-Analysis

Key Points

• To evaluate the efficacy and safety of adjunctive intracoronary low-dose thrombolysis compared with standard primary percutaneous coronary intervention in patients presenting with ST-segment elevation myocardial infarction.
• Systematic review and meta-analysis of clinical trials evaluating intracoronary administration of low-dose thrombolytic agents during primary percutaneous coronary intervention.
• Assessment of post-procedural angiographic perfusion metrics, microvascular flow restoration, and adverse bleeding outcomes across selected studies.
• Adjunctive intracoronary low-dose thrombolysis significantly enhances microvascular reperfusion and coronary blood flow parameters compared to standard primary PCI.
• The local administration of low-dose thrombolytics shows no significant increase in major adverse bleeding events or overall procedural complications.