
Electrophysiology
Pacemakers, ICDs, and CRT outcomes
Synthesized from 137 evidence-backed clinical questions linked to this topic — 2 supporting the intervention, 2 against the intervention, 7 still contested.
No clear lean — the placed evidence is contested
2
Favor benefit
1% of all
2
Favor harm
1% of all
126 more (92%) still untested — not placed on the axis.
Insufficient certainty on 97% of questions
Does antidepressants vs placebo improve outcomes in Cardiac pacemaker twiddler syndrome?
Low Certainty+ Favors benefitantidepressants vs placebo
16 studies (1,125,900 patients) provide low-certainty evidence for benefit of antidepressants for the outcome in Cardiac pacemaker twiddler syndrome.
Does subcutaneous implantable cardioverter-defibrillators (s-icds) vs placebo improve outcomes in Premature battery depletion?
Low Certainty− Favors harmsubcutaneous implantable cardioverter-defibrillators (s-icds) vs placebo
2 studies (6,892 patients) provide low-certainty evidence against benefit of subcutaneous implantable cardioverter-defibrillators (s-icds) for the outcome in Premature battery depletion.
Does crt-d device vs placebo improve outcomes in cardiac implantable electronic device (cied) infection?
Low Certainty− Favors harmcrt-d device vs placebo
2 studies (1,699 patients) provide low-certainty evidence against benefit of crt-d device for the outcome in cardiac implantable electronic device (cied) infection.
Does conduction system pacing (csp) vs placebo improve outcomes in permanent pacemaker indication?
Low Certainty+ Favors benefitconduction system pacing (csp) vs placebo
4 studies (214 patients) provide low-certainty evidence for benefit of conduction system pacing (csp) for the outcome in permanent pacemaker indication.
Does icd implantation vs placebo improve outcomes in complication aspects?
Insufficient~ Mixed resultsicd implantation vs placebo
3 studies (114,484 patients) provide insufficient evidence with mixed findings regarding icd implantation for the outcome in complication aspects.
Does cephalosporium roseum extract vs placebo improve outcomes in permanent pacemaker implantation date?
Insufficient~ Mixed resultscephalosporium roseum extract vs placebo
2 studies (228 patients) provide insufficient evidence with mixed findings regarding cephalosporium roseum extract for the outcome in permanent pacemaker implantation date.
Does subcutaneous implantable cardioverter defibrillator (s-icd) vs placebo improve outcomes in Wolff-Parkinson-White Syndrome?
Insufficient~ Mixed resultssubcutaneous implantable cardioverter defibrillator (s-icd) vs placebo
2 studies (5,494 patients) provide insufficient evidence with mixed findings regarding subcutaneous implantable cardioverter defibrillator (s-icd) for the outcome in Wolff-Parkinson-White Syndrome.
Does subcutaneous implantable cardioverter defibrillator (s-icd) vs placebo improve Inappropriate ICD Shocks in Wolff-Parkinson-White Syndrome?
Insufficient~ Mixed resultssubcutaneous implantable cardioverter defibrillator (s-icd) vs placebo · Inappropriate ICD Shocks
2 studies (5,494 patients) provide insufficient evidence with mixed findings regarding subcutaneous implantable cardioverter defibrillator (s-icd) for Inappropriate ICD Shocks in Wolff-Parkinson-White Syndrome.
No claims extracted for this topic
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Cardiac device therapy (also known as ICD, pacemaker, CRT). Pacemakers, ICDs, and CRT outcomes
As of 2026-08-21, the scientific consensus on Cardiac device therapy is unknown. No claims extracted for this topic
This evidence brief synthesizes Synapse's enriched cardiology corpus; cite as synapsesocial.com/topics/cardiac-device-therapy.
Deterministic synthesis from Synapse's enriched corpus — 43 words. No AI-generated novel content; every figure is sourced from the underlying paper, guideline, or trial record linked on this page.
Explore every Cardiac device therapy paper on Synapse with AI-enriched clinical evidence, PICO analysis, and methodology classification.
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