Supplementary figure S2 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Key Points

• Decr2 knockdown in OCI-Ly8 tumor cells led to resistance against CD19-CAR T cell killing in vitro.
• B16.SIY tumors with Decr2 knockdown demonstrated resistance to anti-PD-L1 therapy in vivo.
• The research highlights the importance of Decr2 in regulating ferroptosis related to tumor response.
• Understanding the role of Decr2 may help improve immunotherapy strategies against cancers.