FIGURE 3 from Single-Cell CD4 and CD8 T-Cell Secretome Profiling Reveals Temporal and Niche Differences in Acute Myeloid Leukemia Following Immune Checkpoint Blockade Therapy

Key Points

Cytokine expression in CD4 cells differs significantly at baseline, showing higher levels in complete responders.
Complete responders exhibit notably higher CD4 effector cytokine expression compared to non-responders.
Exploratory analysis across immune checkpoint blockade therapy settings focuses on CD4 and CD8 T-cell profiles in acute myeloid leukemia patients. No significant variation in functional group expression from CD8 cells exists between complete responders and non-responders.

Abstract

Exploratory analysis of CR and NR patients at baseline. CRs have significantly higher CD4 effector cytokine expression than NRs in the BM. No significant difference in functional group expression from CD8 cells in either PB and BM between CR and NR.

FIGURE 3 from Single-Cell CD4 and CD8 T-Cell Secretome Profiling Reveals Temporal and Niche Differences in Acute Myeloid Leukemia Following Immune Checkpoint Blockade Therapy

Key Points

Abstract

Cite This Study

Also Consider

Also Consider