April 28, 2021Open Access
View Full PaperPulsed Field Ablation of Paroxysmal Atrial Fibrillation
Structured PICO
Does PVI with a single-shot PFA catheter provide durable isolation and safety in patients with paroxysmal atrial fibrillation?
P
Population
Patients with paroxysmal atrial fibrillation
I
Intervention
Pulmonary vein isolation (PVI) with a "single-shot" pulsed field ablation (PFA) catheter
O
Outcome
PVI durability, safety, and 1-year rate of atrial arrhythmia recurrence
PVI with a single-shot PFA catheter demonstrates excellent durability, acceptable safety, and low 1-year recurrence rates for paroxysmal atrial fibrillation.
Abstract
PVI with a "single-shot" PFA catheter results in excellent PVI durability and acceptable safety with a low 1-year rate of atrial arrhythmia recurrence. These data mitigate concern that the nonthermal ablative mechanism of PFA might mask undiscovered compromises to clinical success. (IMPULSE: A Safety and Feasibility Study of the IOWA Approach Endocardial Ablation System to Treat Atrial Fibrillation, NCT03700385; A Safety and Feasibility Study of the FARAPULSE Endocardial Ablation System to Treat Paroxysmal Atrial Fibrillation, NCT03714178; PEFCAT II Expanded Safety and Feasibility Study of the FARAPULSE Endocardial Multi Ablation System to Treat Paroxysmal Atrial Fibrillation PEFCAT II, NCT04170608).