Why the study?
Does the relationship between blood pressure and mortality vary by functional and cognitive status in older adults aged 75+?
Population
1,587 outpatients aged 75 years and over from the Milan Geriatrics 75+ Cohort Study
Comparison
Systolic and diastolic blood pressure levels vs Different blood pressure ranges
Design
Cohort
Follow-up
10-year
Key result
Systolic blood pressure <120 mmHg was associated with higher 10-year mortality compared to SBP 160-179 mmHg in outpatients aged ≥75 years (HR 1.64; 95% CI 1.21-2.23; P=0.001).
Authors
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Low SBP may signal higher mortality risk in frail elderly outpatients; leaves open whether targets should vary by functional status.
Cohort (n=1,587)
Does the relationship between blood pressure and mortality vary by functional and cognitive status in older adults aged 75+?
Effect estimate: HR 1.64 (95% CI 1.21-2.23)
p-value: p=0.001
In older adults aged 75+, the relationship between blood pressure and mortality is U-shaped, and higher systolic blood pressure is associated with lower mortality specifically in those with impaired functional and cognitive status.
Ogliari et al. (2015) conducted a cohort in Geriatric outpatients (n=1,587). Systolic blood pressure < 120 mmHg vs. Systolic blood pressure 160-179 mmHg was evaluated on 10-year mortality (HR 1.64, 95% CI 1.21-2.23, p=0.001). Systolic blood pressure <120 mmHg was associated with higher 10-year mortality compared to SBP 160-179 mmHg in outpatients aged ≥75 years (HR 1.64; 95% CI 1.21-2.23; P=0.001).
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