Why the study?
Does the association of systolic blood pressure with mortality differ with respect to cognitive function in very old individuals?
Population
1115 participants aged 85, 90, and at least 95 years from the Umeå85+/GErontological Regional DAtabase…
Comparison
Systolic blood pressure levels vs SBP 126-139 mmHg
Design
Cohort
Follow-up
2 years
Key result
In very old individuals with severe cognitive impairment (MMSE 0-10), systolic blood pressure ≥165 mmHg significantly increased 2-year all-cause mortality compared to 126-139 mmHg (HR 4.54).
Authors
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High SBP may raise mortality in severe cognitive impairment; hypothesis-generating and should not yet alter practice.
Cohort (n=1,115)
Yes
Does the association of systolic blood pressure with mortality differ with respect to cognitive function in very old individuals?
Effect estimate: HR 4.54 (95% CI 1.52-13.60)
p-value: p=0.007
In very old individuals with severe cognitive impairment, both low (≤125 mmHg) and high (≥165 mmHg) systolic blood pressure are associated with increased 2-year mortality.
Weidung et al. (2016) conducted a cohort in Cognitive impairment and hypertension (n=1,115). Systolic blood pressure ≥165 mmHg vs. Systolic blood pressure 126-139 mmHg was evaluated on All-cause mortality within 2 years (HR 4.54, 95% CI 1.52-13.60, p=0.007). In very old individuals with severe cognitive impairment (MMSE 0-10), systolic blood pressure ≥165 mmHg significantly increased 2-year all-cause mortality compared to 126-139 mmHg (HR 4.54).