July 29, 2025Open Access

Gut microbiota shapes cancer immunotherapy responses

WLWanting LeiCentral South University KZKexun ZhouSichuan Cancer Hospital YLYe LeiNeijiang Normal University

Key Points

Gut microbiota plays a crucial role in determining the success of cancer immunotherapy treatments.
Clinical and preclinical studies indicate that microbiota-based strategies improve immune response and treatment efficacy.
Interventions such as FMT and probiotics show promise in reducing adverse immune-related events during therapy.
Advancing microbiota-focused therapies could refine precision immunotherapy approaches for cancer patients.

Abstract

The gut microbiota significantly influences cancer immunotherapy efficacy by modulating immune responses, remodeling the tumor microenvironment (TME), and producing key metabolites. Strategies such as FMT, probiotics, and dietary interventions show promise in enhancing responses to ICIs and ACTs while reducing immune-related adverse events (irAEs). This review summarizes clinical and preclinical findings and discusses microbiota-based interventions and future directions for precision immunotherapy.

Demander à l'IA

Bookmark

View Full Paper