Colour M-mode tissue Doppler imaging showed cats with hypertrophic cardiomyopathy had lower peak early diastolic myocardial velocity gradients (E1) than normal cats (5.71 vs 11.38 sec-1; P<0.001).
Case-Control (n=37)
Does colour M-mode tissue Doppler imaging detect differences in myocardial velocity gradients between healthy cats and cats with hypertrophic cardiomyopathy?
Colour M-mode tissue Doppler imaging demonstrates decreased myocardial velocity gradients during diastole and systole in cats with hypertrophic cardiomyopathy, allowing discrimination from healthy myocardium.
Absolute Event Rate: 5.71% vs 11.38%
p-value: p=<0.001
OBJECTIVES: To determine whether decreased diastolic and systolic myocardial velocity gradient between the endocardium and the epicardium exist in the left ventricle of cats with hypertrophic cardiomyopathy. METHODS: Myocardial velocity gradient and mean myocardial velocities were measured by colour M-mode tissue Doppler imaging in the left ventricular free wall of 20 normal cats and 17 cats with hypertrophic cardiomyopathy. RESULTS: The peak myocardial velocity gradient (sec(-1)) during the first (E1) (5.71+/-1.75 versus 11.38+/-3.1, P<0.001) and second phase (E2) (3.09+/-1.53 versus 7.02+/-3.1, P=0.005) of early diastole and also the maximum early diastolic myocardial velocity gradient (Emax) (6.12+/-2.1 versus 10.76+/-3.2, P<0.001) were reduced in cats with hypertrophic cardiomyopathy compared with normal cats. Peak myocardial velocity gradient during early systole (Se) was lower in affected cats than in normal cats (6.26+/-2.08 versus 8.67+/-2.83, P=0.006). Affected cats had a lower peak mean myocardial velocities (mm/s) during the two isovolumic periods (IVRb and IVCb) compared with normal cats (2.97+/-6.76 versus 12.74+/-5.5 and 22.28+/-9.96 versus 38.65+/-10.1, P<0.001, respectively). CLINICAL SIGNIFICANCE: This study shows that hypertrophic cardiomyopathy cats have decreased myocardial velocity gradient during both diastole and systole and also altered myocardial motion during the two isovolumic periods. Myocardial velocity gradients recorded by colour M-mode tissue Doppler imaging can discriminate between the healthy and diseased myocardium.
Koffas et al. (Tue,) conducted a case-control in Hypertrophic cardiomyopathy (n=37). Colour M-mode tissue Doppler imaging vs. Normal cats was evaluated on Peak myocardial velocity gradient during the first phase (E1) of early diastole (p=<0.001). Colour M-mode tissue Doppler imaging showed cats with hypertrophic cardiomyopathy had lower peak early diastolic myocardial velocity gradients (E1) than normal cats (5.71 vs 11.38 sec-1; P<0.001).
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