Figure S22 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• B7-H3 CAR T cells effectively reduce tumor size in ependymomas, but the efficacy is limited by immune response and tumor characteristics.
• IHC evaluation highlighted significant CD3+ cell infiltration in ZFTA-RELA EPN tumors, supporting the targeted immune response.
• This analysis relies on IHC methods to assess the tumor microenvironment and immune interactions within ependymomas.
• These findings suggest that further research is needed to better understand limitations on CAR T cell therapies in solid tumors.